Feeding of diet containing various doses of curry leaves 5, 10 and 15% to normal rats for 7 days as well as mild diabetic blood glucose levels 175 mgdl induced by alloxan 35 mgkg ip and moderate diabetic rats blood glucose levels 250 mgdl induced by stz 60 mgkg ip. Antidiabetic activity of some herbal plants in streptozotocin. Open in a separate window antimicrobial efficacy of extracts all the six double combinations of the plant extracts were effective in inhibiting the growth of s. The present study aimed to investigate the antidiabetic effect of murraya koenigii mk leaf extracts, of two different solvent ratios. This is the simplest known group of carbazole alkaloids. Phytochemical portfolio and anticancer activity of murraya koenigii and its primary active component, mahanine. The medicinal plant murraya koenigii shown to have a wide variety of pharmacological activities hypoglycemic and hypolipidemic. Naturally occurring carbazole alkaloids from murraya koenigii. Leaves of the plant have much value as an antidiabetic, antioxidant, antimicrobial, anti.
The aqueous extract of murraya koenigii leaves has been taken to evaluate the hypoglycemic activity in normal and alloxan induced diabetic rabbits. Protective effect of murraya koenigii l leaves extract in. Hypoglycemic activity of murraya koenigii meethaneem leaves. Psidium guajava, pg and catharanthus roseus, cr were used to test their antidiabetic activity in streptozotocin stz induced diabetic albino rats. The scientific evaluation of hypoglycemic and antidiabetic activity of freeze dried leaves of murraya koenigii was carried out in normal and streptozotocininduced sub and mild diabetic rats. Antidiabetic activity of herbal drugs dwiti modak ayurvedic pharmacy, lovely school of pharmaceutical sciences, lovely professional university, phagwara, punjab, india dwiti.
It belongs to family rutaceae which represent more than 150 genera and 1600 species. Evaluation of antidiabetic activity of murraya koenigii on alloxan. The antioxidant activity in murraya koenigii is mainly attributed to carbazole alkaloids tachibana et al. Hypoglycemic and antihyperglycemic activity of murraya. Herbal antidiabetic drugs are prescribed widely because of their effectiveness, less side effects and relatively low cost19. The murraya species has richest source of carbazole alkaloids. The antioxidative properties of the leaves extracts of murraya koenigii using different solvents were evaluated based on the oil stability index osi together with their radical scavenging ability against 11diphenyl2picrylhydrazyl dpph. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats. Naturally occurring carbazole alkaloids from murraya. Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5.
The structure of koenoline 64, which was obtained for the first time as a natural product, was established with the aid of. Antihyperglycemic activity of murraya koenigii leaves extract. References patel d, patel hn, pathak k, venkatraghvan s, pharmacy education series. Evaluation of antidiabetic effect of murraya koenigii. International journal of pharma and bio sciences v122010. Previous studies reported koja bay leaves has many pharmacological activities such as antidiabetic, antihypertension, anti. Aqueous extract of leaves of 3 herbs murraya koenigii, mk. In addition, murraya koenigii exhibited a pro found antioxidant effect with decreased mda level and increased gsh level, particularly at the 200 mgkg b.
Koja bay leaves murraya koenigii which mostly cultivated in indonesia and the leaves usually used by aceh people as a flavoring agent for food, has been known to have an antidiabetic effectin this study, we analyzed the antidiabetic effect of koja bay leaves tea bags which commercially available. Screening of invitro hypoglycemic activity of murraya koenigii and. Murraya koenigii leaf extract inhibits proteasome activity. These include antioxidant, antidiabetic, antiinflammatory, antitumor. Antidiabetic effect of murraya koenigii leaves aqueous. Suvagiya 5 faculty of pharmaceutical sciences, pacific university 1, udaipur, rajasthan, india. Medicinal profile, phytochemistry, and pharmacological. Pharmacological properties of the extract and some isolated. Antidiabetics activity of salam koja murraya koenigii. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Antidiabetic effect of murraya koenigii ksu faculty. Present work conducted on murraya koenigii illustrates its antidiabetic and antioxidant activities using various biochemical tests. Pdf antidiabetic properties and phytochemical studies.
The murrayakoenigii curry tree is a tropical to sub tropical tree in the family rutaceae, which is a native in india. The aqueous extract of the leaves of murraya koenigii after oral as well as intravenous administration to normal and alloxan diabetic dogs produced the hypoglycemia. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and research 612. The in vitro thrombolytic property of curry leaves murraya koenigii and palak spinacia oleracea was determined by using human blood. Murraya koenigii, commonly known as curry leaves is native to india. Murraya koenigii has diverse role in traditional medicine and is known for its stomachic properties. Antidiabetic potential of murraya koenigii roots in. The results was comparable to standard compound glibenclamide. Murraya koenigii is a potential medicinal plant highly valued for its characteristic aroma and bioactive compounds. However, there is a need to conduct further pharmaceutical analysis on test extracts in order to establish these biomedical applications. The study of plants having antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment. Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5 1school of pharmacy, chouksey engg. The stzna diabetic rats were treated with an ethanolic extract of murraya koenigii 200 mgkg b. Hypoglycemic effects of murraya koenigii on normal and.
The leaves of murraya koenigii are also used as an ingredient in ayurvedic medicine. Anticolon cancer activity of murraya koenigii leaves is due to constituent murrayazoline and omethylmurrayamine a induced mtorakt downregulation and mitochondrial apoptosis. The treatment of diabetes type ii is complicated due to the inherent pathophysiological factors related to this disease. Pharmacological activities of murraya koenigii and its primary bioactive. This plant is promising as it is widely and regularly used as a spice for food flavoring and as such it appears to be without any side effects and toxicity. Pdf the antidiabetic activity of curry leaves murraya koenigii. Thus the aim of the present work was to evaluate the antidiabetic activity of fruit juice of murraya koenigii. Sakarkar department of pharmacology and physiology sudhakarrao naik institute of pharmacy, nagpur road, pusad 445204 m. Evaluation of antidiabetic effect of murraya koenigii leaves. Antidiabetic activity of curry leaves murraya koenigii on. Arulselvan p1, senthilkumar gp, sathish kumar d, subramanian s. Antioxidative activity of carbazoles from murraya koenigii leaves.
Hydroalcoholic and alkaloidal extracts of murraya koenigii. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes article pdf available august. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxaninduced diabetic albino rats model. Activity of proline and its analogs isolated from murraya. Protective effect of murraya koenigii l leaves extract in streptozotocin induced diabetics rats involving possible antioxidant mechanism s. Pdf antidiabetic effect of murraya koenigii leaves on.
The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced. Murraya koenigii, a plant belonging to the rutaceae family is widely distributed in easternasia and its medicinal properties are well documented in ayurveda, the traditional indian system of medicine. Research article total phenolic content estimation. Green leafy vegetable consumption has been associated with decreased risk of persistent metabolic diseases. As an herb, it offers potential uses in fat loss such as. Asin the present study, murraya koenigii meethaneem leaves collected from udaipur, rajasthan aqueous slurry exhibited a statistically significant p value koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite and it has been reported to have antioxidant, antidiabetic, antidysenteric, antimicrobial, antiinflammatory, hepatoprotective and antihypercholesterolemic activities11,12. The commonly used spice curry patta murraya koenigii is traditionally consumed by diabetics in southern part of india. India is considered as the worlds diabetic capital.
Protective effect of murraya koenigii leaves extract instreptozotocin induced diabetic rats involving possible antioxidant mechanism. Antidiabetic potential of murraya koenigii roots in alloxan. A single oral administration of variable doses of 100, 200, 300 and 400 mg kg1 lowered blood glucose level in normal and diabetic rats. The antidiabetic activity of curry leaves murraya koenigii on the. The methylene chloride ch2cl2 extract and the ethyl acetate etoac soluble fraction of the 70% acetone extract significantly prolonged the osi values. Glibenclamide was used as a standard reference drug. It contains several bioactive compounds like euchrestine b, bismurrayafoline e, mahanine, mahanimbicine, mahanimbine 8 and essential oil 9 which contribute to antioxidative, hypoglycaemic, antitrichomonal, blood protective and hepatoprotective effects. This study was to evaluate the ethnomedical uses of the stem bark in in. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Traditionally, the leaves are used as a herb in ayurvedic medicine. The chlorhexidine produced the least inhibition zone against s.
Mk, pg and cr are given to the stz induced diabetic rats at the concentration of 500 mgkg body weight in different groups of 6 diabetic rats each orally once a day for 15 days. A study on a highly medicinal plant murraya koenigii. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxan. Murraya koenigii can be used to cure the symptoms of variety of diseases. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and.
Murraya koenigii is an aromatic and more or less deciduous shrub or small tree up to 7 meters in height and 14 to 42 cm in diameter raghunathan, et al. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats dr. Yankuzoa adepartment of basic medical science, kulliyyah of medicine, international islamic university malaysia. The present study was carried out to evaluate the antidiabetic effect and histological parameters of. The two variant doses of koja bay leaves tea bag 411.
The antidiabetic properties and phytochemical studies of fractions of ethanolic leaf extract 400mgkgb. Pdf evaluation of antidiabetic activity of murraya koenigii. Pdf the antidiabetic activity of curry leaves murraya. Comparative study of in vitro antioxidant and antidiabetic activity of plant extracts of acacia arabica murraya koeingii catharanthus. Potential antidiabetic herbal medicines html full text. Antidiabetic and hypolipidemic effects of mahanimbine carbazole alkaloid from murraya koenigii rutaceae leaves. Since adequate characterization of antidiabetic activity of murraya koenigii aqueous extract has not yet been done and considering that highest amount of brcs was found to be present in murraya koenigii leaves, an attempt was made to investigate the antihyperglycaemic activity of aqueous extract of murraya koenigii leaves and compare it with. Murraya koenigii is found in himalaya, sikkim, kerala, tamil nadu, andhra pradesh, maharashtra and assam2. Effect of murraya koenigii leaf extract on carbohydrate. Leaves of murraya koengii was used for the flavouring purpose. Phytochemical profile of murraya koenigii leaves shows the presence of some vitamins, carbazole alkaloids, triterpenoids, mineral contents such as iron, calcium, zinc and vanadium, and phenolic compounds chakrabarty et al. Hypoglycemic activity of murraya koenigii meethaneem. Evaluation of antidiabetic activity of murraya koenigii on. Antidiabetic effect of murraya koenigii l and olea.
In the present study, antihyperglycemic effect of oral administration of ethanolic extract of m. Therefore, the present study was designed to characterize the biochemical and physiological parameter for its possible biological effects and safety at long time administration of fruit juice of murraya koenigii in terms of 28 days repeated dose toxicity study. Murraya koenigii is semi deciduous, aromatic smell spreading shrub or tree with strong woody stem but slender with the stem which is dark green to brownish in color the tree is 48. However, interesting to isolate the compounds responsible for antidiabetic activity and to elucidate their mechanism of action. Hypoglycemic activity studies on root extracts of murraya. Thin layer chromatography, murraya koenigii bark, phytochemical screening. Their properties include much value as an antidiabetic 91 and hepatoprotectant 92. Murraya koenigii curry leaf may bring blood sugarbalancing activity to weight loss formulas. After the administration of murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Conclusions the present study reveals that murraya koenigii possesses antidiabetic activity and antioxidant effects on stz. Various parts of murraya koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite 2.
Hydroalcoholic and alkaloidal extracts of murraya koenigiil. Murraya koeinigii for its any biological activities. Assessment of antidiabetic and antioxidant activity of. Studies on carbazoles isolated from murraya koenigii leaves have been shown to possess antioxidant and antimicrobial activity 93 95. Antidiabetic activity of curry leaves murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats imad m. One of the complications of diabetes is postprandial hyperglycemia pphg. Pdf evaluation of thrombolytic activity of murraya. Evaluation of antidiabetic efficacy of murraya koenigii on streptozotocin. Antidiabetic effect of murraya koenigii leaves on streptozotocin induced diabetic rats. Phytochemical portfolio and anticancer activity of murraya. Antioxidative activity of carbazoles from murraya koenigii. The highly valued part of the plant is the leaves which possess various biological activities.
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