Epidemiology and risk factors of patients with types of acute coronary syndrome presenting to a tertiary care hospital in sri lanka article pdf available in bmc cardiovascular disorders 191. Unstable angina occurs when the blood clot causes a reduced blood flow but not a total blockage. This is a cross sectional descriptive study conducted at the teaching hospital peradeniya, sri. The occurrence and effect of risk factors differ by type ofacs. Moreover, the prevalence of metabolic syndrome ms is higher in populations with acs than in the general population. Acute coronary syndrome symptoms and causes mayo clinic. Such estimates have been shown to have moderate to high sensitivity for ace but are conservative. Highspeed electrocardiogram ecg has shown good accuracy of the initial diagnosis and of the final diagnosis in treated cardiac patients.
Low risk moderate risk high risk unstable angina e t nstemi appropriately elevated troponin stemi stelevation on ecg evolution continuum of acute coronary syndrome evaluating from a process perspective occlusive event consider this a missed opportunity this is mis evolve really bad. Epidemiological studies in the sri lankan population are limited. Novel atherosclerotic risk factors and angiographic. Myocardial infarction mi, a subset of acute coronary syndrome, is damage to the cardiac muscle as evidenced by elevated cardiac troponin levels in the setting of acute ischemia. Risk factors of clinical types of acute coronary syndrome. Predisposing risk factors of acute coronary syndrome acs. Sex differences in epidemiology and risk factors of acute coronary syndrome in chinese patients with type 2 diabetes. Risk factors associated with acute coronary syndrome in. Traditional risk factors of acute coronary syndrome in. These are, with rare exceptions table 181, a consequence of acute thrombus formation related to a disrupted coronary atherosclerotic plaque. Is a man over 45 years of age or a woman over 55 years of age. One hundred and fifty six patients with acs were investigated in intensive care unit icu, at cardiac center in king khalid hospital, in northern ksa, city of hail. Acute coronary syndrome american heart association. Cardiovascular diseases cause approximately onethird of all deaths in the world, of which 7.
Compared with men, despite the wellknown older age and more pronounced frailty, women with acs present later from symptom onset and are at high bleeding risk after invasive. The aim of this study was to find out the common risk factors associated with acute coronary syndrome acs in northern kingdom of saudi arabia ksa. There are three clinical entities grouped under acs. Traditional risk factors of acute coronary syndrome in four. Acute coronary syndrome an overview sciencedirect topics. Acute coronary syndrome robert bender, do, facoi, facc central maine heart and vascular institute. Considerable research is being conducted in the field. However, other potentially modifiable risk factors smoking, diabetes, hypertension, dyslipidaemia, obesity. Acute coronary syndrome often reflects a degree of damage to the coronaries by atherosclerosis.
This study sought to identify the accuracy of physician. Oct 21, 2019 acute coronary syndrome acs is one of the leading causes of death worldwide and studies have shown higher mortality rates and premature death in south asian countries. Decades of research have helped to clarify the risk factors associated with atherosclerosis and ami onset out of the hospital. Those wellknown conditions are both acute coronary syndromes, an umbrella term for situations where the blood supplied to the heart muscle is suddenly blocked. Acute coronary syndrome causes, risk factors, symptoms. Among the wellknown risk factors for atherosclerosis, obesity was the most prevalent in this series. Knowing your risk factors may help explain how you might have gotten the diseaseand help you avoid further damage by improving some of your lifestyle choices.
Known clinical risk factors for the different manifestations of cardiovascular disease cvd, such as cad, peripheral artery. Acute coronary syndrome acs has been estimated to affect 1. The term acute coronary syndrome covers a broad spectrum of clinical situations, from unstable angina to stsegment elevation myocardial infarction stemi. The aim of this metaanalysis was to detect risk factors for depression among patients with acs and to provide clinical evidence for its prevention. To investigate the hypothesis that risk factors may be differently related to severity of acute coronary syndromes acs, with st elevation used as a marker of severe acs. Myocardial infarction or mi acute myocardial infarction or ami heart attack coronary thrombosis coronary occlusion angina or chest pain.
One such condition is a heart attack myocardial infarction when cell death results in damaged or destroyed heart tissue. Acs is associated with substantial morbidity and mortality and places a large financial burden on. An electrocardiogram ecg or ekg can diagnose an acute coronary syndrome by measuring the hearts electrical activity. Cardiovascular risk factors for acute coronary syndrome acs are on rise in people of indian origin. The prognosis for patients with acs is affected by several factors, such as baseline characteristics and treatment before, during and after hospitalisation.
The young womens risk paradox in patients with acute coronary syndrome cannot be explained by a lower quality of care, as assessed by prior work. The incidence of ihd in general, and of acs, increases with age although, on average, this occurs 710. Ua to nonst segment elevation myocardial infarction. Context given the numerous, yet inconsistent, reports of genetic variants being associated with acute coronary syndromes acs, there is a need for comprehensive validation of acs susceptibility genotypes.
Risk factors associated with acute coronary syndrome after. In order to implement prevention measures effectively, analyses of the prevalence of cv risk factors in general population and acute coronary syndrome acs patients are. Risk factors for repeat percutaneous coronary intervention in. The risk factors and prevention of cardiovascular disease. Primary prevention of atherosclerosis is controlling the risk factors.
Risk factors and epidemiology of coronary heart disease in endstage renal disease dialysis risk factors for adverse outcomes after stelevation myocardial infarction. Family history of chest pain, heart disease or stroke. According to the virgo study, almost 98% of young patients 1855 years with acute myocardial infarction have one or more risk factors for cad and 64% have three or. Hypertension, ischemic heart disease ihd, smoking, diabetes miletus dm, and dyslipidemia were. The risk factors for acute coronary syndrome acs are similar to those for other types of heart disease. Coronary artery disease cad, acute coronary syndromes acs, and other conditions related to atherosclerosis are leading causes of death in developed countries. Although our study cannot explore further causality, there are multiple potential factors that may contribute to high risk in younger women, including psychological and social stressors. The term acute coronary syndrome acs covers a range of disorders, including a heart attack myocardial infarction and unstable angina, that are caused by the same underlying problem.
This will facilitate an understanding of the pathophysiological changes that can lead to acute coronary syndrome. Coronary artery disease and acute coronary syndrome in. Association of major cardiovascular risk factors with the. We analyzed traditional cvd risk factors in four populations of males with acute coronary syndrome acs from prague, czech republic, kaunas, lithuanian republic and astana, kazakhstan and compared them with control populations. The most common risk factors for acs in northern ksa hail region were dyslipidemia and hypertension. Acute coronary syndrome acs describes the range of myocardial ischemic states that includes unstable angina, nonst elevated myocardial infarction mi, or stelevated mi. Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the united states. The incidence of ihd in general, and of acs, increases with age although, on average, this occurs 710 years earlier in men compared with women. A comparative study was performed to compare the distribution of risk factors and complications in patients with acute coronary syndrome acs at high vs lowaltitude areas in yemen. In two countries, the most robust acs risk factor was smoking.
Acute coronary syndromes, just like heart failure and strokelink opens in new window, are much more likely in people who have certain risk factors. A great proportion of the patients with acs had an age range of 46. Coronary artery disease and acute coronary syndrome in women. Minute by minute, the heart is accumulating irreversible damage. Importance acute coronary syndrome acs, the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide and is responsible for more than 1 million hospital admissions in the united states annually. The incidence of depression is very common among patients with post acute coronary syndrome acs and leads to adverse outcomes.
Apr 11, 2019 acute coronary syndrome is a term used to describe a range of conditions associated with sudden, reduced blood flow to the heart. These programs provide patients with education, regular exercise, monitoring risk factors, and addressing lifestyle modifications needed to. Acute coronary syndrome refers to a range of conditions in which too little blood can reach the heart, for example, because of a blockage. Acute coronary syndrome acs is one of the major causes of mortality in the world. These risk factors are useful on a population basis to identify cohorts at higher risk of coronary artery disease, but their utility for individual patient risk prediction is limited, except potentially in younger patients. Prevalence and impact of cardiovascular risk factors among patients presenting with acute coronary syndrome in the middle east. So youve never heard of an acute coronary syndrome. A study of risk factors in young patients of acute coronary syndrome. A study of the cardiovascular risk factor profile in patients. Objective to perform an extensive validation of putative genetic risk factors for acs. The signs and symptoms of acs constitute a continuum of intensity, from unstable angina. Acute coronary syndrome is a leading cause of emergency medical treatment and hospitalization in poland. Dosing practices and risk factors for bleeding in patients.
Background emergency physicians frequently assess risk of acute cardiac events aces in patients with undifferentiated chest pain. Acute coronary syndromes acs and sudden death cause most ihdrelated deaths, which represent 1. Even when acute coronary syndrome causes no cell death, the reduced blood flow changes. Risk factors for acute coronary syndrome in patients below. Risk factor management after acute coronary syndrome. Consequences depend on degree and location of obstruction and range from unstable angina to nonstsegment elevation myocardial infarction nstemi, stsegment elevation myocardial infarction stemi, and. Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syn drome events quickly in any clinical setting. Acs often reflects a degree of damage to the coronary arteries by atherosclerosis. Epidemiology of acute coronary syndromes oxford medicine.
Pdf sex differences in epidemiology and risk factors of. Epidemiology and risk factors of patients with types of acute. Acute coronary syndrome in young people is an increasing health problem. The following factors increase your chances of developing acute coronary syndrome. Family physicians need to identify and mitigate risk factors early, as well as. Therefore, the aim of the present study was to assess risk factors associated with acute coronary syndrome in northern saudi arabia. Clinical and genetic risk factors in acute coronary syndromes.
Risk factors associated with acute coronary syndrome. Among the cases of acs, st elevation myocardial infarction stemi were 23. Association of cardiovascular risk factors with the different. Risk factors for acute coronary syndrome in patients below the age. The study aimed to establish the prevalence of acs, to analyse the risk factors, forms of clinical presentation, and outcomes of the patients with acs treated from 2006 to 2010 in the coronary unit cu in leskovac. Jun 02, 2018 acute coronary syndrome in young people is an increasing health problem. The presence of type 2 diabetes mellitus magnifies the risks associated with acute coronary syndrome acs, increasing the risk of recurrent cardiovascular events cves and doubling the risk of. Acute coronary syndromes result from acute obstruction of a coronary artery. The risk factors for coronary artery disease cad include hypercholesterolemia, hypertension, diabetes mellitus dm, smoking and obesity. If tests confirm blood flow to the heart has been blocked, doctors will work quickly to reopen the artery. Pdf risk factors associated with acute coronary syndrome. The incidence of depression is very common among patients with post acute coronary syndrome acs and leads to adverse outcomes aims.
Materials and methods this is a retrospective descriptive study conducted in coronary care unit ccu at king khalid hospitalcardiac centre, hail, ksa. There are important dissimilarities in clinical presentation, aggregation of comorbidities, cardiovascular risk factors and the quality of delivery of medical care among men and women with acute coronary syndrome acs. Cardiovascular risk factors and mortality among acute. It is crucial to make an early and accurate diagnosis of acs with risk stratification to guide therapy accordingly. Pdf risk factors associated with acute coronary syndrome in. Nonvalidation of reported genetic risk factors for acute. Thus, the aim of the study was to evaluate the cardiovascular risk factor profile of patients presenting with acute coronary syndrome and to study the prevalence. Over the past decade the treatment of these syndromes has changed dramatically. Therefore, the search for risk factors has also been thorough. These two conditions cannot be reliably distinguished in all cases, and patients with acs have been shown to benefit from aggressive clinical management, including angioplasty andor thrombolysis. Acute coronary syndrome knowledge for medical students.
A great proportion of the patients with acs had an age range of 46 59 years 47. If the arteries to the heart become narrowed or blocked, the heart receives insuffi cient oxygen, thereby causing angina andor myocardial infarction mi, the 2 conditions that fall under the heading of acs. The risk of acute coronary syndrome increases with age and is greater in men and in people with a family history. Acute coronary syndrome acs is a clinical symptom complex that corresponds to unstable angina and acute mi.
Pdf epidemiology and risk factors of patients with types. Atherosclerotic coronary disease is still a leading cause of death within developed countries and not surprisingly, is significantly rising in others. Diagnosis and management of acute coronary syndrome. The hematocrit is the major determinant of whole blood viscosity, increased hematocrit level is associated with decreased cerebral blood. Acute coronary syndrome acs refers to acute myocardial ischemia andor infarction due to partial or complete occlusion of a coronary artery. Gut microbiotadependent trimethylamine noxide in acute coronary syndromes. Coronary risk factors in acute coronary syndrome patients in. Acute coronary syndrome a c u t e c o r o n a r y s y n d r o m e m a r d i g i a n w e l l n e s s r e s o u r c e c e n t e r page 1 other names.
Recognition and treatment of these factors may prevent readmission for such a dangerous condition and may improve outcomes. A prognostic marker for incident cardiovascular events beyond traditional risk factors. Risk factors for repeat percutaneous coronary intervention. Factors influencing prognosis in acute coronary syndrome. Novel risk stratification assays for acute coronary syndrome. Risk stratification after nonst elevation acute coronary syndrome. Several clinical and angiographic factors identify patients at high risk for acute coronary syndrome after successful percutaneous coronary intervention. To describe dosing practices and to identify risk factors for bleeding in patients with an acute coronary syndrome acs who received treatment with enoxaparin. Bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome christine macie, md.
Epidemiology and risk factors of patients with types of. Pdf prevalence and impact of cardiovascular risk factors. Characteristics and outcome in acute coronary syndrome patients. Acute coronary syndrome acs is one of the leading causes of death worldwide and studies have shown higher mortality rates and premature death in south asian countries.
A study of the cardiovascular risk factor profile in. Cardiovascular risk factors and clinical presentation in. The risk factors for atherosclerosis include the following. Acute coronary syndrome, cardiovascular risk factors, prevention. Treatment of acs patients with or without modifiable risk factors was similar with regard to interven tional therapies and use of. Acute coronary syndromes have been often reported to occur in patients without risk factors and with normal coronary arteries,1517. Risk factors for atherosclerosis in this section, the pathophysiology of atherosclerosis and coronary artery disease cad will be discussed.
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